E’s on Antibiotics: Bad News? HYPOTHETICAL QUESTION: Would really appreciate some information here. Does anyone know what happens if a person combines e and antibiotics? Is it a definite no go (i.e you'll die), unrecommended (like with alcohol because you get mashed) or not really an issue? I would really appreciate an answer if anyone knows this or has any thoughts folks. Mwah x
Ecstasy users Hey everyone. I'm a psychology student doing my dissertation about ecstasy use and mood, I really need people to participate. All it is is a couple of questionnaires, its all explained below. If you want to take part just copy the lot into an email and send it to memyselfanddanny@hotmail.com, any help would be massively appreciated.
Thanks,
Danny
I would firstly like to thank you for taking part in the study, and to inform you that this research is subject to ethical guidelines that have been set out by the British Psychological Society. You have the right to withdraw from the study at any point, and your completing and returning the questionnaires will be taken as a sign that you give written consent for the data to be used in the research. A written report of the findings of the study will be carried out, and the report may also include presentation at academic conferences or articles in academic journals. However, your identity will remain anonymous throughout the whole process, and what little personal information is taken is simply for the purposes of matching the questionnaires together.
The study will consist of 2 questionnaires which you are required to fill in. The first is a Drugs History Questionnaire, which consists of 10 questions that you should answer as honestly as possible, and is to determine your level of drug use (If you do not use ecstasy then just leave out the ecstasy related questions and just do the other bits). The second is a Profile of Mood States Questionnaire consisting of 65 items, words which you should rate on a scale of 1 (not at all) to 4 (quite a bit), relating each to how you have felt over the past week. The only requirement when filling in the questionnaire is that you have not taken ecstasy within the past 4 days, as due to the nature of the study this would have a major effect on the outcome. The two questionnaires should take in total no more than about 20 minutes to complete.
If any of the issues raised by either of the questionnaires causes any distress, the following are 24 hour, confidential helplines that you can call:
Samaritans - 08457 909090
National Drugs Helpline - 0800 776600
Drugs History Questionnaire
1 Your Age:
2 Your Gender:
3 Your age when you first started using Ecstasy:
4 Do you currently consider yourself an Ecstasy user?
5 How many days has it been since you last used Ecstasy?
6 Roughly how many Ecstasy pills would you take in one session?
7 How often are the sessions when you use ecstasy? (eg. Daily, Monthly, Yearly etc)
8 How many times have you used Ecstasy in your lifetime? (This does not have to be an exact figure, but please try to be as accurate as possible)
9 Please list any other recreational drugs you have used in your lifetime, and the number of days since you last used each of them:
10 Do you use any of these on a regular basis? Please list those that you do.
11 Are you currently, or have you ever studied at University?
Mood States Questionnaire
Below is a list of words that describe feelings people have. Please read each one carefully. Then score it either 0, 1, 2, 3 or 4 to describe how you have been feeling over the past 2 days.
The numbers refer to these phrases:
0 = Not at all
1 = A Little
2 = Moderately
3 = Quite a bit
4 = Extremely
Friendly
Tense
Angry
Worn out
Unhappy
Clear-headed
Lively
Confused
Sorry for things done
Shaky
Listless
Peeved
Considerate
Sad
Active
On edge
Grouchy
Blue
Energetic
Panicky
Hopeless
Relaxed
Unworthy
Spiteful
Sympathetic
Uneasy
Restless
Unable to concentrate
Fatigued
Helpful
Annoyed
Discouraged
Resentful
Nervous
Lonely
Miserable
Muddled
Cheerful
Bitter
Exhausted
Anxious
Ready to fight
Good natured
Gloomy
Desperate
Sluggish
Rebellious
Helpless
Weary
Bewildered
Alert
Deceived
Furious
Efficient
Trusting
Full of pep
Bad tempered
Worthless
Forgetful
Carefree
Terrified
Guilty
Vigorous
Uncertain about things
Bushed
Feedback on the questionnaires is incredibly helpful to me, so if you have any comments about them then please feel free to add them below:
The strange case of the man who took 40,000 ecstasy pills in nine years The strange case of the man who took 40,000 ecstasy pills in nine years
[FONT=arial,helvetica,sans-serif]· Usage increased to 25 tablets a day at peak
· Memory problems and paranoia may be lasting[/FONT]
[FONT=Geneva,Arial,sans-serif]David McCandless
Tuesday April 4, 2006
The Guardian
[/FONT]Doctors from London University have revealed details of what they believe is the largest amount of ecstasy ever consumed by a single person. Consultants from the addiction centre at St George's Medical School, London, have published a case report of a British man estimated to have taken around 40,000 pills of MDMA, the active ingredient in ecstasy, over nine years. The heaviest previous lifetime intake on record is 2,000 pills.
Though the man, who is now 37, stopped taking the drug seven years ago, he still suffers from severe physical and mental health side-effects, including extreme memory problems, paranoia, hallucinations and depression. He also suffers from painful muscle rigidity around his neck and jaw which often prevents him from opening his mouth. The doctors believe many of these symptoms may be permanent.
The man, known as Mr A in the report in the scientific journal Psychosomatics, started using ecstasy at 21. For the first two years his use was an average of five pills per weekend. Gradually this escalated until he was taking around three and a half pills a day. At the peak, the man was taking an estimated 25 pills every day for four years. After several severe collapses at parties, Mr A decided to stop taking ecstasy. For several months, he still felt he was under the influence of the drug, despite being bedridden.
Hallucinations
His condition deteriorated and he began to experience recurrent tunnel vision and other problems including hallucinations, paranoia and muscle rigidity. "He came to us after deciding that he couldn't go on any more," said Dr Christos Kouimtsidis, the consultant psychiatrist at St George's Medical School in Tooting who treated him for five months. "He was having trouble functioning in everyday life."
The doctors discovered that the man was suffering from severe short-term memory problems of a type usually only seen in lifetime alcoholics. But evaluating the full extent of his condition was difficult as his concentration and attention was so impaired he was unable to follow the simple tasks involved in the test.
"This was an exceptional case. His long- term memory was fine but he could not remember day to day things - the time, the day, what was in his supermarket trolley," said Dr Kouimtsidis. "More worryingly, he did not seem aware himself that he had these memory problems."
With no mental illness in his family and no prior psychiatric history, the doctors concluded that his unique condition was direct result of his intense ecstasy use.
"This is obviously an extreme case so we should not blow any observations out of proportion," says Dr Kouimtsidis. "But if this is what is happening to very heavy users, it might be an indication that daily use of ecstasy over a long period of time can lead to irreversible memory problems and other cognitive deficits."
For 10 years, MDMA has been suspected of causing these kinds of effects in heavy users. It is thought to be due to its disruption of the regulation of serotonin, a brain chemical believed to play a role in mood and memory. It remains unclear whether these effects are the result of permanent neurotoxic damage or just temporary reversible alterations in the brain.
A study today in a special MDMA issue of the British Journal of Psychopharmacology, suggests long-term side-effects may be temporary.
The researchers from the University Of Louisiana could find no significant relationship between depression and recreational ecstasy use.
In the case of Mr A, a structural MRI brain scan failed to show any obvious damage or atrophy in his brain. However, these results, says Dr Kouimtsidis, are difficult to interpret. "A scan of this type is not sensitive enough," he said.
Such limitations in brain scanning technology, along with ethical and legal barriers to giving MDMA to human test subjects, have limited direct observation of the drug's effects in humans.
Instead, scientists have had to use recreational drug users as subjects in their studies. Conclusions from this are often flawed because few, if any, drugs users use ecstasy in isolation.
Cannabis user
Mr A was also a heavy cannabis user, and when he was encouraged to decrease his use, his paranoia and hallucinations disappeared and his anxiety abated. But his memory and concentration problems remained, leading the doctors to suspect that these may be permanent disabilities.
When he was admitted to a specialist brain injury unit and put on anti-psychotic medication, he did start to show some improvement.
"Unfortunately, he discharged himself before we were able to complete the assessment," says Dr Kouimtsidis. "We continued to support him. But he started to use cannabis again and he dropped out. We tried to re-engage him but we lost him about a year ago."
The Guardian made several attempts to find the man without success.
Effects of ecstasy
MDMA is one the most intensely studied recreational drugs in history. But despite thousands of research papers and studies, scientific evidence on the side-effects remains inconclusive.
Death by overdose
Undoubtedly, large amounts of ecstasy can lead to over-heating which in turn, in rare cases, can trigger fatal heat stroke. Many factors contribute: number and strength of pills taken, environment, alcohol-consumption, body weight - but women seem more at risk. The bulk of ecstasy-related deaths around the world have been young women.
Water-poisoning
Panicking users, fearing they are overdosing, drink too much water and provoke hyponaetraemia (water-poisoning). Leah Betts died after drinking 14 pints in just 90 minutes. The recommended amount of water to drink per hour is one pint.
Toxic reactions
Much of the reports of toxic reactions are muddled with overdose or water-poisoning deaths. There is no clear evidence that some people suffer allergic reactions to ecstasy. However, around 10% of Western users do lack a key liver enzyme CYP2D6 needed to break down MDMA. This may make them more sensitive to the effects and more prone to accidental overdose.
Depression
Many weekend users report a mid-week mood dip. This is suspected to be related MDMA's effect on serotonin, but hard evidence is lacking. In heavy users, dips can turn to crashes and depression. However studies suggest this effect reverses after a 2-3 month abstinence.
Positive effects
Users still claim "long lasting improvements in self-awareness, self-esteem, openness and insight into personal problems", reports the study from the University Of Louisiana. In the US, research continues into the use of MDMA-assisted psychotherapy to treat Post Traumatic Stress Disorder.
Ecstasy survey, please take part! As there seems to be lots of interest on the subject,
I would like to invite you all to participate in a small survey which
is part of a research project on Ecstasy (MDMA) that I am currently
conducting as my thesis.
It literally takes 10 minutes to complete and all you have to do is click on the link!
http://www.surveymonkey.com/s.asp?u=820231800596
Whether you are, have been, or are not an Ecstasy/MDMA user, your
input will be quite valuable to the ongoing research on the matter,
which unfortunately has so far been quite controversial and biased.
Please help me shred some light on this very important issue!
Thank you all for your help and support!
Love and Light
FW: We buy MDMA
the1log wrote:
kevv74 wrote:
Can you help us out???
We can make a fortune
Best
Kevin
nyimagestudios@yahoo.com
got this message the other day,
its spining me out...
Got any idea who kev74 is?
I'm about to ask the person involved not to do it again. Although it seems innocent, Log's a bit sensitive about it and I'd like to reassure him we can protect his privacy...
hugh
Shark Pills My BF has picked up yet another new pill, called Sharks, in East Anglia area.
Anyone tried them? I don't mind being the guinea pig tho!
(Still saving the remainder of my Supermen for Glade...)
PLUR
Moody pills warning – London Got some pills on Saturday for a trip to the George IV - flat, light blue with no score or logo. They came from a reasonably trusted source so I started with half, then another 1-and-half followed quite quickly.
Virtually no come-up, just a tight chest, odd heartbeat and a trip to casualty. Still getting occasional twinges in my chest now on Monday morning.
Be careful...
What E’s are in your area at the moment? Just wondering what different kinds of E can be found in different areas at the moment.......
Where im from (NW UK)..its white smiles (pretty rubbish)
before that green shrek 2's...
whats in your area?12
Superman Pills Hey all,
Interested to know what anyone thought of Superman pills?
I used to think Shrek 2's were the business but now, these are my faves. They must have really high MDMA content along with the perfect dosage of speed, because they were amazingly quick, I swear I started to come up really quick, within 10 minutes. It normally takes me a half hour or more.
Nice loved-up pill which lasted a looong time, After a few hours sleep last Saturday morning I was still rushing for 2 days. And I only necked 2. No tooth-grinding action, nice heavy rushes, and no noticeable comedown... I complained when I bought them cos they were expensive (£4 each) but! I would pay twice as much for them again and be happy.
If you can get hold of any, do... they are class.
Did anyone else out there try 'em?
:omg_no: Keep it movin all night long
PLUR
E Connections? Just moved to Zurich from Canada, and missing my contacts dearly, would really like to find a couple of cool clubs/parties full of friendly people with Ecstatic substances to share on the weekends. Please help!
Cheers,
L
Please help me find some e / mdma Just moved from the Canadian countryside to Zurich, had e here once before (from a friend) and adored it, would love to get some more, but have no idea where to start.... can anyone give me a suggestion?
Pills: White Smileys got some white smiles at the weekend...
they are absolutley rubbish...
i took 14 in 10 hours....came up but didnt realy peak.
stay away.
there a bright white colour ,quite thick, round indented eyes..
no good whatsoever.
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