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Topic Tag: provigil
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Fast facts on DMT
Here are some key points about DMT. More detail and supporting information is in the main article.
DMT has been used as a drug for thousands of years.
Use of the drug as part of shamanic ritual is common in South America.
Side effects include powerful hallucinations.
Due to the nature of the drug, DMT is known as the “spirit molecule.”
DMT is a white crystalline powder that is derived from certain plants found in Mexico, South America, and parts of Asia, such as Psychotria viridis and Banisteriopsis caapi.
It is typically consumed in the following ways:
vaporized or smoked in a pipe
consumed orally in brews like ayahuasca
snorted or injected on rare occasions
The chemical root structure of DMT is similar to the anti-migraine drug sumatriptan, and it acts as a non-selective agonist at most or all of the serotonin receptors, particularly at the serotonin 5-ht2a receptor. Serotonin is a neurotransmitter that has a large effect on the majority of our brain cells.
There is some evidence that DMT is also produced endogenously, in other words, it is produced naturally in the body, specifically in the pineal gland in the brain.
When smoked, the average dose of DMT is believed to be somewhere between 30 to 150 milligrams (mg), and the onset of action can be felt almost instantly. The effects peak and plateau for 3 to 5 minutes, and gradually drop off with the duration of effect totaling 30 to 45 minutes.
When consumed as a brew, the dose is between 35 to 75 mg. Effects begin after 30 to 45 minutes, peak after 2 to 3 hours and are resolved in 4 to 6 hours.
DMT street names
DMT is referred to by a number of slang terms:
dimitri
businessman’s trip
businessman’s special
fantasia
forty-five-minute psychosis
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December 11, 2021 at 11:43 pm
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Modafinil (Provigil)
So, I started this thread as a place for people to share about their experiences with modafinil (aka Provigil), one of the most popular cognitive enhancers or "smart drugs".
If you don't know what Modafinil is, here is a description (I'll also upload some additional resources below):
Modafinil, a novel cognitive enhancer, selectively improves neuropsychological task performance in healthy volunteers and adult patients with attention deficit hyperactivity disorder (ADHD). It has been argued that persistent cognitive deficits in patients with schizophrenia are responsible for the failure of many patients to rehabilitate socially even when psychotic symptoms are in remission. The present study examined the potential of modafinil as a cognitive enhancer in schizophrenia. Twenty chronic patients with a diagnosis of schizophrenia were entered into a double-blind, randomized, placebo-controlled crossover study using a 200 mg dose of modafinil. Modafinil had some cognitive enhancing properties in schizophrenia similar to those observed in healthy adults and adult patients with ADHD. Improvement was seen on short-term verbal memory span, with trends towards improved visual memory and spatial planning. This was accompanied by slowed response latency on the spatial planning task. No effect on stop-signal performance was seen. Importantly, significant improvement in attentional set shifting was seen, despite no effect of modafinil on this task being seen in healthy volunteers or ADHD patients. Modafinil may have potential as an important therapy for cognitive impairment in patients with schizophrenia, particularly because of its beneficial effects on attentional set shifting.
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August 17, 2017 at 7:35 am
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