First Reported Fatalities Associated with the ‘Research Chemical’ 2-Methoxydiphenidin

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First Reported Fatalities Associated with the ‘Research Chemical’ 2-Methoxydiphenidin

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February 25, 2015 at 8:34 pm

#684714
1

tryptameanie

@tryptameanie

Participant
The full article is behind a paywall sadly so I can only share the abstract. In case you don’t know, methoxphenidine is the methoxy ester (someone correst me) of diphenidine which is itself a potend xissociative. Here’s the exptract.

2-Methoxydiphenidine, i.e. 1-[1-(2-methoxyphenyl)-2-phenylethyl]piperidine, also known as ‘MXP’ or ‘2-MeO-diphenidine’ (or 2-MXP), has been available as a ‘research chemical’ since 2013 as a purported alternative to the ‘dissociative anesthetics’ methoxetamine and ketamine. Three deaths which involved the detection of 2-MXP in post-mortem blood and urine were encountered in forensic casework. The 2-, 3- and 4-methoxyphenyl positional isomers were synthesized to confirm the identity and concentration of 2-MXP. The 2-MXP femoral blood concentrations in the cases were found to be 24.0, 2.0 and 1.36 mg/L (the latter with an alternative cause of death). Some additional prescription drugs were encountered at therapeutic concentrations in all three cases. Analysis of the biofluids allowed the detection and characterization of various metabolites, including the suggested presence of hydroxy-2-MXP as the main metabolite with the hydroxyl group located on the piperidine rather than the phenyl or benzyl moiety. Additional metabolites included O-desmethyl-2-MXP and hydroxylated O-desmethyl-2-MXP. Diphenidine and hydroxy-diphenidine, also showing the presence of the hydroxyl group on the piperidine ring, were also detected. It was not possible to identify whether these arose from 2-MXP biotransformation or whether they represented the presence of diphenidine as a separate substance. These are the first published fatalities involving 2-MXP and presents analytical data to assist analytical toxicologists with future casework.”
February 25, 2015 at 8:39 pm

#842983
1

EPICLULZ

@epiclulz

Participant
Are you a reporter for The Sun news paper now? it’s all they go on about
February 25, 2015 at 8:45 pm

#842988
1

tryptameanie

@tryptameanie

Participant
News is just news mate, good or bad. I’m not surprised it’s killed people, more surprised it took this long.

Abstract from a scientific journal is hardly like pulling something out of the daily lies.
February 25, 2015 at 9:12 pm

#842995
1

isocortex

@isocortex

Member
Love ya work mate … Keep em coming
there’s a key bit of information that the report fails to elaborate on:

Some additional prescription drugs were encountered at therapeutic concentrations in all three cases

I’d bet my right nut that they contributed to the deaths
February 25, 2015 at 9:13 pm

#842989
1

tryptameanie

@tryptameanie

Participant
I’d absolutely agree with you.
February 25, 2015 at 10:48 pm

#842980
1

Garoldeep Singh

@garoldeep-singh

Member
Same, ‘good’ drugs aka prescription medication is never taken in to account as its consistently labeled ‘good for you’, ‘not the issue’ and/or ‘unable to kill people’.
February 26, 2015 at 1:47 am

#842984
1

Digital Buddha

@digital-buddha

Participant
@Gylfì Guðbjörnsson 591329 wrote:

Same, ‘good’ drugs aka prescription medication is never taken in to account as its consistently labeled ‘good for you’, ‘not the issue’ and/or ‘unable to kill people’.

like when they rolled Oxycontin out and said less than 1% of patients would get addicted…
February 26, 2015 at 2:06 am

#842986
1

Iliesse

@iliesse

Participant
Subscriber
@Tryptameanie 591313 wrote:

The full article is behind a paywall sadly so I can only share the abstract. In case you don’t know, methoxphenidine is the methoxy ester (someone correst me) of diphenidine which is itself a potend xissociative. Here’s the exptract.

2-Methoxydiphenidine, i.e. 1-[1-(2-methoxyphenyl)-2-phenylethyl]piperidine, also known as ‘MXP’ or ‘2-MeO-diphenidine’ (or 2-MXP), has been available as a ‘research chemical’ since 2013 as a purported alternative to the ‘dissociative anesthetics’ methoxetamine and ketamine. Three deaths which involved the detection of 2-MXP in post-mortem blood and urine were encountered in forensic casework. The 2-, 3- and 4-methoxyphenyl positional isomers were synthesized to confirm the identity and concentration of 2-MXP. The 2-MXP femoral blood concentrations in the cases were found to be 24.0, 2.0 and 1.36 mg/L (the latter with an alternative cause of death). Some additional prescription drugs were encountered at therapeutic concentrations in all three cases. Analysis of the biofluids allowed the detection and characterization of various metabolites, including the suggested presence of hydroxy-2-MXP as the main metabolite with the hydroxyl group located on the piperidine rather than the phenyl or benzyl moiety. Additional metabolites included O-desmethyl-2-MXP and hydroxylated O-desmethyl-2-MXP. Diphenidine and hydroxy-diphenidine, also showing the presence of the hydroxyl group on the piperidine ring, were also detected. It was not possible to identify whether these arose from 2-MXP biotransformation or whether they represented the presence of diphenidine as a separate substance. These are the first published fatalities involving 2-MXP and presents analytical data to assist analytical toxicologists with future casework.”

Was this fatal death part of a study involving humans?, or was this chemical coupound which should only in the first steps of research study on animals been diverted for consumption.

Does the article give the info of which prescripted drugs was taken by these persons?
February 26, 2015 at 2:06 am

#842981
1

Garoldeep Singh

@garoldeep-singh

Member
@Digital Buddha 591348 wrote:

like when they rolled Oxycontin out and said less than 1% of patients would get addicted…

Diazipam, clonazipam, adderall blah blah blah

After watching a Edward Snowden documentary earlier on channel 4, I know get this feeling that he might also have found possible financial/medical links within the CIA (a given, they were known to torture people with lsd and other things to gain information as well as feed there sick fantasies), NSA etc.

I’ve suffered from pretty bad depression since I was like 11, and spent a very long time taking bloody anti-depressants, which numb you, which make you think ‘mehh’, which keep you sedated….all a bit of a co-inki-dink I think, but I am pretty fuckin high so most likely over thinking it, but I kind believe myself in it.
February 26, 2015 at 2:06 am

#842982
1

Garoldeep Singh

@garoldeep-singh

Member
@Digital Buddha 591348 wrote:

like when they rolled Oxycontin out and said less than 1% of patients would get addicted…

Diazipam, clonazipam, adderall blah blah blah

After watching a Edward Snowden documentary earlier on channel 4, I know get this feeling that he might also have found possible financial/medical links within the CIA (a given, they were known to torture people with lsd and other things to gain information as well as feed there sick fantasies), NSA etc.

I’ve suffered from pretty bad depression since I was like 11, and spent a very long time taking bloody anti-depressants, which numb you, which make you think ‘mehh’, which keep you sedated….all a bit of a co-inki-dink I think, but I am pretty fuckin high so most likely over thinking it, but I kind believe myself in it.
February 26, 2015 at 2:09 am

#842990
1

tryptameanie

@tryptameanie

Participant
Every drug is dangerpous to a degree. The most damngerous thing about a new drug is no-one knows it’s effect or potency and MXP has fucked me twice.
February 26, 2015 at 2:31 am

#842985
1

Digital Buddha

@digital-buddha

Participant
dosage is the difference between theraputic and posion
February 26, 2015 at 6:56 am

#842978
1

p0ly

@p0ly

Participant
I have tried Dipehidine, it is a truly DISGUSTING drug. I mean that wholeheartedly, not only did it make me very ill to my stomach when I took it orally, nasally it felt so damn toxic, I decided to try and just finish what I had and I had an abnormal reaction where my whole face broke out in intense white head spots, I’m talking about over 50 of the things. I was fucking terrified when I saw my complexion, I have never had such a reaction to an RC. I checked the site which sold it and funnily enough it’d been removed, I messaged them asking why it’d been removed and I got no reply.

These RC Dissociatives are to be avoided, they are foul fucking shit.
February 26, 2015 at 6:59 am

#842991
1

tryptameanie

@tryptameanie

Participant
I got sent 3 grams of MXP insread of the 3g EPG I ordered. Had a reasonable line b4 i walked to my f=dad n by thetime I got there I was a totAL fucking mess.
February 26, 2015 at 7:05 am

#842979
1

p0ly

@p0ly

Participant
I tried MXP and it really messed me up too, in quite a nice way. It was combined with Coke and Booze too… Probably Xanax too thinking back.
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