Party Vibe

tiletamine is usually combined with zolezepam – a benzodiazepine (i.e a sleeping tablet type drug, the sort of thing given to old codgers to help them sleep and forget about the war etc…) this would explain why it is less trippy (and possibly more “tiring”)

this is a coroners report from an unfortunate Korean chap.

[font=Arial, Helvetica, sans-serif]A Fatality Due To Injection of Tiletamine and Zolazepam[/font] [font=Arial, Helvetica, sans-serif]A 22-year-old male with more than 28 needle marks on his right arm was found dead. First, he was suspected as a drug abuser. Blood, urine, spleen, and injection-site tissue was collected during autopsy. The blood and urine specimens were screened for drugs. Immunoassay studies did not show any illegal drugs. However, two unidentified peaks were isolated in both of these biological fluids by routine gas chromatography–flame-ionization detection (GC–FID) and thermionic specific detection. Additional gas chromatography–mass spectrometry analysis determined these two peaks to be tiletamine and zolazepam. These two agents are used in combination as veterinary anesthesia. The concentrations of these drugs in blood were quantitated by GC–FID and found to be 0.85 mg/L of tiletamine and 3.3 mg/L of zolazepam. In urine, tiletamine and its metabolite, 2-(ethylamino)-2-(2-thionyl) cyclohexanol, were identified to be present along with zolazepam. The concentrations of tiletamine and zolazepam in spleen were revealed to be 0.92 and 3.5 mg/kg, respectively. Injection-site tissue concentrations were determined to be 25.1 mg/kg tiletamine and 23.3 mg/kg for zolazepam. The cause of death in this case was determined to be due to the multiple drug intoxication of tiletamine and zolazepam.[/font][font=Arial, Helvetica, sans-serif]Heesun Chung, Hwakyung Choi, Eunmi Kim, Wontack Jin, Hanyoung Lee, and Youngchan Yoo
National Institute of Scientific Investigation, 331-1 Shinwol-dong, Yangchon-ku, Seoul, Korea 158-097[/font]

here is a report of it being found in French festivals (teknivals?) around 2002.

7 mars 2002

Première identification de Tiletamine

Le dispositif SINTES (Système d’identification national des toxiques et substances) piloté par l’Observatoire Français des Drogues et des Toxicomanies, vient d’identifier un nouveau produit très toxique circulant dans les milieux festifs (ou au cours des événements festifs).

La tilétamine, anesthésique vétérinaire, a été mise en évidence par l’un des laboratoires des centres d’évaluation et d’information sur la pharmacodépendance (CEIP) participant au programme SINTES.
les CEIP fonctionnent en réseau et sont coordonnés par l’Afssaps

Le produit se présente sous la forme d’une poudre blanche. Il est proposé comme ” cristaux de kétamine vétérinaire “. Consommé en ” sniff “, ce produit a donné lieu à des troubles neurologiques (convulsions, catatonie), généraux (dépression respiratoire, hyperthermie) et du comportement graves justifiant l’ interventions d’équipes médicales et sanitaires.

and a report from the British veterinary association which claims the stuff (administered on its own) is quite frankly not fit for dogs!

This stuff is clearly more dangerous than real K and best avoided IMO

Papers & Articles
Effects of tiletamine/zolazepam premedication on propofol anaesthesia in dogs
LK Cullen and JA Reynoldson

School of Veterinary Studies, Murdoch University, Australia.

The cardiovascular and pulmonary effects of tiletamine/zolazepam, propofol and tiletamine/zolazepam plus propofol were studied in five mongrel dogs. A cannula inserted into a raised carotid artery was used to measure mean arterial pressure (MAP) and heart rate continuously and to collect arterial blood for the determination of pH, PO2, PCO2, bicarbonate and base balance. Respiratory frequency and rectal temperature were also recorded. In the two propofol groups premedication had no significant effect on the time to rejection of an endotracheal tube and the return to sternal recumbency. The MAP and heart rate increased after tiletamine/zolazepam alone and after tiletamine/zolazepam plus propofol, although propofol alone reduced MAP and transiently increased heart rate. Respiratory frequency decreased transiently in both propofol groups in association with a significant increase in PaCO2 and decrease in PaO2. The most notable change was the hypoxaemia in the tiletamine/zolazepam plus propofol group in which the PaO2 was reduced. In all the dogs given tiletamine/zolazepam alone undesirable side effects were observed, effects which also occurred during the recovery of the dogs given tiletamine/zolazepam plus propofol.