Well Im no chemist or Doctor so can only post from the experience of me and my mates which consists of several years of taking MDMA every Friday night (and sometimes Saturdays to ) in late teens to mid 20s, ranging from 1-3 pills plus often a g of wizz, then 2-3 years of taking Drone, again Friday nights though not every week like the pilling days, more like every 2nd or 3rd weekend……………
Always had good times when on good stuff ( though a quite a few disappointments on bunk rip offs ), always needed at least a day to recover ( though a large part of that is due to lack of sleep ), never had any sign of seizures or chest pains or schizophrenia.
MDMA – always left me drained for a couple of days afterwars, day after taking would be a w/o smoking tons of weed and just vegging out, following 1-2 would just be tired and lacking motivation to do anything.
Drone – Same on day afterwards, maybe more severe though that could be more down to being older when I took it than I was on MDMA, but recovered faster after a day in bed, though that could be due to lack of weed available.
I do generally have a poor memory, but dont know if thats down to taking LSD in early teens, MDMA & wizz, Drone, or smoking weed for 20 years, or combination of all, or just natural deterioration with age. Paranoia is hard to say, when carrying certainly worried about being caught, and very few people I worked with ever knew what I did on weekends…. but I dont think thats paranoia, thats just being cautious since I didnt want to get busted or lose my job.
Addiction, on drone & MDMA none, like it, want it sometimes, but never felt I needed it. Tobacco I am physically addicted to, and for a long time I would say I was psychologically addicted to weed, got very stressed when I couldnt get any and would never want to get back to the point where I was smoking it every day, or even every week.
NOT saying Drone or MDMA or any other drug/chem is safe or harmless, they all carry risk of and do damage…. but comparatively I would say occasional use in sensible doses is safer and less harmful than tobacco or alcohol, far more enjoyable, and being in clubs/events full of pillheads you are far less likely to get into trouble than drinking clubs.
IMO The biggest long term effects – missed out on career advancement & messed up relationships due to wanting to keep partying forever instead of putting the proper time/effort into these things
