Forums › Drugs › Over the Counter & Prescription Drugs › Norco: Is there a difference between generic brands? Yes! What do you think?
I’ve been taking Norco 10/325 for quite some time and have noticed a MAJOR difference in quality and effectiveness between manufacturers. To me the Mallinckrodt 367 are the most effective all around. Interpharm/Amneal (same commpany/have merged) IP110 version comes in second for me. Watson seems to be the worst with noticeably much less effective pain relief and with me seems to act more like a sedative, knocking me out which sucks when you want to be functional/productive. Qualitest is okay but seems to be similar to the Watsons only with less sedation. Personally if the pharmacy doesn’t carry Mallinckrodt or Interpharm/Amneal then I won’t fill my prescription there. I know this subject has been discussed here many times before but I figure since the recent apparent formula changes in the once preferred brands it’d be good to share with each other our recent experiences. What do you think?
There can be bno difference between the products, these are pharmaceuticalms made to exceptional standards of quality and purity. What you describe is not that uncommon. I know of 2 very srong opiates that would have at least a 50 % chance of any effect. Those paink9llers were tramadol and pethidine. I took 6 grams of tramadol one night, got no effect but did collapse and spend the night in hospital.
I’ve definitely noticed a difference in the effects between brands. I’ve been this medication for a while and when I tried the other brands there was a night and day difference. While the main ingredients should basically be the same there is definitely something different between brands. I don’t know if it’s quality of ingredients, maybe different fillers, or something else but something is causing the effectiveness to differ between brands. I know first hand.
There should only be the same amount of the exact same active compound at exactly the same purity and quality, there are incredibly strict regulations on the quality and purity of anything given as a phatmaceutical. This goes for everything including Illegal drugs used in clinical setting. David Nichols had to produce DMT for a clinical study and the process to make it and make it phatm grade was intense having to reach a purity of over 99% for it to be used, purely because it had to be pharm grade fpr medical use. The difference must be from any sort of filler as you say but everything else in the tablet should be completely inactive. Talk to your doctor about this, maybe he can help.
Ah, I see. Good info to know Requiem, thanks. The solution I’ve found works best for me is to stick to the brand I know works well for me (Mallinckrodt) and life is good. I guess another thing to consider too in general is that everyone responds differently to medications. What works well for one person may not work well for another. I’ve run into that problem with various anti-depressants I’ve tried over the years. Anyhow thanks for the replies and have a good one!
No problem, as you say different people respond differently to different medications but here the medication is exactly the same so that is unlikely. The other crap mixed in, even though considered inactice, may well have an effect on some, much the same of people with nit allergies as they certainly get an effect from them.
What exactly is unlikely?
The acticve compound. As I said, this will be exactly the same in every brand making it unlikely to be the cause of any difference in effects you find. The likely one is the fillers etc.
@Requiem 966810 wrote:
as you say different people respond differently to different medications but here the medication is exactly the same so that is unlikely.
I’m not understanding the point you’re trying to make here. Do you mean that since the active compounds of the generic Norcos are exactly the same that different people aren’t going to have different reactions to it or are you referring to the anti-depressants?
no I am saying that different people will react different;y to the same medications, but the same person should not react different;ly at different times to the same medication.
If we look at your case alone and took several brands of one medication and extracted only the active ingredient from each and gave you on;ly that, you would react the same to each. However if we then took everything else from each rand ad gave you that one by one, then you may well find an effect from one of those .
Does that make sense?
Makes perfect sense and I agree completely. I hadn’t seen your prior post yet:@Requiem 966812 wrote:
The acticve compound. As I said, this will be exactly the same in every brand making it unlikely to be the cause of any difference in effects you find. The likely one is the fillers etc.
because I was busy writing my other response but I understand now what you’re saying. Do you think the fillers have an effect on how the active compound is absorbed or effects the body or do you think it’s strictly the fillers alone causing the noticeable difference in reaction?
No, as I say anything inside a pharmaceutical has to keep everything the same as far as how the medication works in a normal human, with one or 2 exceptions. One I can think of is a modified release version of a compound alowing for a gradual release of it in stead of it all becoming active at once and maybe orodispersable versions as well. Versions of a medication that dissolve on the tongue instead of beong swallowed which will give a faster onset.
Gotcha. Thanks again for the replies and have a good morning.
You’re welcome man and have a good day.
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Forums › Drugs › Over the Counter & Prescription Drugs › Norco: Is there a difference between generic brands? Yes! What do you think?