There’s a lot of rubbish out there about pre and post loading
I’ll pick on one … 5HTP
Perhaps the most commonly reported supplement taken with MDMA is 5-HTP, a serotonin precursor. There are numerous anecdotal reports that taking 5-HTP alone or in combination reduces both unwanted side effects and day-after effects. One paper found that very high doses of injected 5- HTP block MDMA neurotoxicity and 5-HTP has been shown to be an antioxidant, but 5- HTP’s neuroprotective effect may have nothing to do with its being a mild antioxidant.20,2122 It may be that 5-HTP is particularly suited to the task of reducing MDMA’s physical impact by both providing some oxidative protection and supporting the replenishing of serotonin. Unfortunately, it is also possible that 5-HTP could increase the risk of serotonin syndrome and research needs to be done to determine whether this is a practical concern.
Citation: Erowid, Earth. “Do Antioxidants Protect Against MDMA Hangover, Tolerance, and Neurotoxicity?” Erowid Extracts. Dec 2001; 2:6-11.
if you eat 5-htp you run the risk of serotonin syndrome for no proven effects. if you inject it, you run the risk of dying to prevent oxidative stress that could be better and more safely blocked by an SSRI. once again, 5-htp is for the night or two after the roll.
5HTP will not cause any up-regulation. Time, and exercise cause up-regulation. Some studies suggest an SSRE like tianeptine (Tianeptine – Wikipedia, the free encyclopedia)
5-htp does not cause up-regulation, 5-htp only replaces the serotonin that was drained during a roll. useful for avoiding brain zaps and mid-week depression
Your body should make plenty of serotonin from potatoes, beans, bananas etc. 5HTP should never need to be “thrown into the mix” before rolling, and on any long-term usage.
also, mdma metabolites are inhibitors of TPH, the enzyme that makes serotonin from tryptophan. 5-htp is the only way your body can make serotonin immediately following a roll
source: http://www.erowid.org/chemicals/mdma/mdma_neurotoxicity1.shtml#oxidative
Again, 5 HTP is converted to serotonin in the liver, and only 1-2% crosses the BBB. So that means 98-99% of the extra sertonin is being shat and pissed out, after roaming around your bloodstream. Don’t forget, serotonin is a neurotoxin in excessive amounts. It’s one of the chemicals found in bee and wasp venom..
serotoinin is also responsible for causing blood to clot. thats why its in bee venom source:wikipediai encourage you to look into what your ody needs and when and don’t rely on get rich quick schemes selling pills
Oxidisation is another must to research
